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产品简介
| 靶标 | CD8A |
| 别名 | BB154331, CD8 antigen, alpha chain, Cd8a, Ly 2, Ly 35, Ly B, Lyt 2 |
| 宿主 | Rat |
| 稀释比例 | FCM 10^6cells +0.2ug |
| Gene ID | 12525 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P01731 |
| 蛋白分子量 | 32kDa |
| 储存液 | PBS with 0.1% sodium azide and a stabilizer. |
| 亚细胞定位 | Cell membrane Secreted Single-pass type I membrane protein |
| 免疫原 | Spleen cells or thymocyte membranes |
| 亚型 | IgG2a |
| 纯化方法 | Affinity purification |
| 背景资料 | CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells, on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-/CD8+ T cells (PMID: 1968084). |
| 克隆类型 | Monoclonal antibody |
| 交叉反应 | Mouse |
| 规格 | 25ug100ug |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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