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产品简介
| 英文名称 | Anti-EPHA3 Polyclonal Antibody |
| 靶标 | EPHA3 |
| 别名 | EK4;ETK;HEK;ETK1;HEK4;TYRO4 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:2000-5000;IHC 1:50-200. |
| Gene ID | 2042 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P29320 |
| 蛋白分子量 | 61/110kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cell membrane Cytoplasm Nucleus Secreted |
| 免疫原 | A synthetic peptide of human EPHA3 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. |
| Public Immunogen Range | 590-640/983aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human;Mouse;Rat |
| 应用 | WB;IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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