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产品简介
| 英文名称 | Anti-OPA1 Polyclonal Antibody |
| 靶标 | OPA1 |
| 别名 | BERHS;MGM1;MTDPS14;NPG;NTG;largeG |
| 宿主 | Rabbit |
| 预测交叉反应 | Chimpanzee |
| 稀释比例 | WB 1:1000-3000;IHC 1:50-200. |
| Gene ID | 4976 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | O60313 |
| 蛋白分子量 | 107/111/113/117kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | A synthetic peptide of human OPA1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes. Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance. |
| Public Immunogen Range | 175-225/960aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human;Mouse;Rat |
| 应用 | WB;IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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