暂无数据
产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品简介
| 英文名称 | Anti-ITGAV Polyclonal Antibody |
| 靶标 | ITGAV |
| 别名 | CD51;MSK8;VNRA;VTNR;Integrin alpha V;ITGAV |
| 宿主 | Rabbit |
| 预测交叉反应 | Cow;Chicken |
| 稀释比例 | IHC 1:100-300. |
| Gene ID | 3685 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P06756 |
| 蛋白分子量 | 112/116kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cell membrane Cytoplasm |
| 免疫原 | A synthetic peptide of human ITGAV |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation. ITGAV:ITGB3 act as a receptor for CD40LG. |
| Public Immunogen Range | 125-175/1048aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human;Mouse |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
暂无数据
我要询价
*联系方式：
(可以是QQ、MSN、电子邮箱、电话等，您的联系方式不会被公开)
*内容：
