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产品简介
| 英文名称 | Anti-BUB1B Polyclonal Antibody |
| 靶标 | BUB1B |
| 别名 | BUB1beta;BUBR1;Bub1A;MAD3L;MVA1;SSK1;hBUBR1 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:1000-3000;IHC 1:50-200. |
| Gene ID | 701 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | O60566 |
| 蛋白分子量 | 105/119/121kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Nucleus Cytoplasm |
| 免疫原 | A synthetic peptide of human BUB1B |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. |
| Public Immunogen Range | 300-350/1050aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human |
| 应用 | WB;IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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