Anti-PDGFRA Polyclonal AntibodyAnti-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

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产品简介

英文名称	Anti-PDGFRA Polyclonal Antibody
靶标	PDGFRA
别名	CD140A;PDGFR-2;PDGFR2;GAS9;RHEPDGFRA
宿主	Rabbit
预测交叉反应	Chicken;Xenopus laevis
稀释比例	WB 1:1000-3000;IHC 1:50-200.
Gene ID	5156
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	P16234
蛋白分子量	24/83/122kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm Cell membrane Nucleus
免疫原	A synthetic peptide of human PDGFRA
亚型	IgG
纯化方法	Affinity purification
背景资料	Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca2+ and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.
Public Immunogen Range	720-770/1089aa
克隆类型	Polyclonal Antibody
交叉反应	Human;Mouse;Rat
应用	WB;IHC
规格	50ul100ul