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| 英文名称 | Anti-KCTD6 Polyclonal Antibody |
| 靶标 | KCTD6 |
| 别名 | KCASH3 protein |
| 宿主 | Rabbit |
| 预测交叉反应 | ZebraFish |
| 稀释比例 | WB 1:1000-3000. |
| Gene ID | 200845 |
| 保存 | Store at -22°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q8NC69 |
| 蛋白分子量 | 28kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.5. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | Recombinant protein of human KCTD6 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887). |
| Public Immunogen Range | 1-238aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human;Mouse;Rat |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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