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产品简介
| 英文名称 | Anti-PMEPA1 Polyclonal Antibody |
| 靶标 | PMEPA1 |
| 别名 | Protein TMEPAI;STAG1;TMEPAI |
| 宿主 | Rabbit |
| 稀释比例 | IHC 1:50-200. |
| Gene ID | 56937 |
| 保存 | Store at -48°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q969W9 |
| 蛋白分子量 | 26/28/32kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.31. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | Recombinant protein of human PMEPA1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). |
| Public Immunogen Range | 1-238aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human;Mouse |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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