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产品简介
| 英文名称 | Anti-KITLG Polyclonal Antibody |
| 靶标 | KITLG |
| 别名 | Kit ligand;MGF;SCF;c-Kit ligand;sKITLG;MGF;SCF |
| 宿主 | Rabbit |
| 预测交叉反应 | Bovine;Chicken |
| 稀释比例 | IHC 1:100-300. |
| Gene ID | 4254 |
| 保存 | Store at -65°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P21583 |
| 蛋白分子量 | 27/28/31kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.48. |
| 亚细胞定位 | Cell membrane Cytoplasm |
| 免疫原 | Recombinant protein of human KITLG |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
| Public Immunogen Range | 1-20214aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human;Mouse;Rat |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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