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产品名称
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产品简介
英文名称 | Anti-IGHM Polyclonal Antibody |
靶标 | IGHM |
宿主 | Rabbit |
稀释比例 | IHC 1:50-200. |
Gene ID | 3507 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
Swiss Prot | P01871 |
蛋白分子量 | 49/52kd |
储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
亚细胞定位 | Cytoplasm Cell membrane |
免疫原 | Recombinant protein of human IGHM |
亚型 | IgG |
纯化方法 | Affinity purification |
背景资料 | IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553). |
Public Immunogen Range | 248-597aa |
克隆类型 | Polyclonal Antibody |
交叉反应 | Human;Mouse |
应用 | IHC |
规格 | 50ul100ul |
注意:
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
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